Arginine HCl 6%
Nitric-oxide donor
A precursor to nitric oxide, which dilates blood vessels. Increased blood flow to vulvar and clitoral tissue is the foundation of arousal physiology.

A prescription topical for female libido, arousal, and sensitivity — three vasoactive actives that target arousal physiology directly.
Arginine increases blood flow, Papaverine relaxes smooth muscle, Alprostadil enhances vasodilation and sensitivity. Together they address the underlying physiology of female arousal.
Important Safety InformationConsultation Included
This is a prescription-strength product. Your order includes a free medical consultation with one of our licensed providers.
How it works:
If our providers determine this treatment isn't appropriate for you, your card authorization is released — you're never charged.
Proven Ingredients
Three vasoactive actives, each addressing one of the three physiological pathways that drive female arousal. Compounded in a topical cream for direct, localized application.
Nitric-oxide donor
A precursor to nitric oxide, which dilates blood vessels. Increased blood flow to vulvar and clitoral tissue is the foundation of arousal physiology.
Smooth-muscle relaxant
A long-established vasodilator that relaxes smooth muscle in vascular and erectile tissue. Enhances local engorgement when applied topically.
Prostaglandin E1
Originally developed for male erectile dysfunction; topical Alprostadil increases vulvar/clitoral blood flow and sensitivity in women.
Female arousal is physiology, not willpower. Topical actives target the physiology directly — and the clinical data is solid.

Dr. Annie Ressalam, MD
Internist · Medical Director, HerTeleMeds
The science
Arousal isn't emotional alone — it's a vascular and neural process. Three things happen when the physiology is supported.
↑ Blood flow
Increased circulation to clitoral and vulvar tissue is the first step of arousal. Hormonal shifts at perimenopause can blunt this response.
Smooth muscle
Smooth muscle in vascular and erectile tissue must relax for engorgement. Papaverine has been used clinically for this since the 1970s.
Nerve response
Local prostaglandin signaling sensitizes nerve endings. Alprostadil enhances this pathway when applied topically.
Trusted by thousands
After my hormones shifted in my 40s, intimacy felt different. This brought a real, physical response back.
— HTM Patient, CA
My skin felt like a stranger's after menopause. Her Arousal brought it back home.
— HTM Patient, TX
Discreet shipping, clear instructions, and it actually works. The whole experience was professional.
— HTM Patient, FL
Personalize your treatment
Hair thinning has different drivers at different life stages. Here's how HairMax addresses the most common concerns at each.
Arousal and sensation shifts after childbirth. Topical vasodilation supports the return to baseline blood flow and sensitivity.
Cortisol blunts the arousal response. Topical actives bypass the hormonal feedback loop and act directly on tissue.
Some hormonal contraceptives reduce circulating testosterone and arousal. Topical Rx provides an option without changing your contraceptive plan.
The mechanism
Each active addresses a distinct physiological step in the arousal response. Together, they cover the full pathway.
Arginine HCl drives nitric-oxide-mediated vasodilation, increasing circulation to clitoral and vulvar tissue.
Papaverine HCl relaxes vascular smooth muscle in erectile and surrounding tissue, allowing engorgement.
Alprostadil sensitizes nerve endings via prostaglandin E1, restoring physical sensation locally.
Eligibility
Her Arousal Rx contains three vasoactive actives. Most adults can use it safely — but cardiovascular conditions and certain medications require a conversation with your provider before starting.
Dr. Ressalam reviews these factors during the intake — Her Arousal is only prescribed when it's appropriate. If declined, your card authorization is released and you are never charged.
Pricing
Her Arousal Rx bundles compounded Arginine HCl + Papaverine HCl + Alprostadil, a physician visit, and discreet shipping into one monthly cost.
Her Arousal Rx
Traditional regimen
Monthly cost
$89 / mo
Flibanserin (Addyi) ~$99/mo + visit
Dermatologist visit
Included
$150–$300 separate
Treatment route
Topical cream
Daily oral pill
Shipping
Free, discreet
Pharmacy pickup
Provider follow-up
Anytime
Per appointment
Comparison reflects branded oral flibanserin (Addyi) at typical 2026 retail. Topical compounded prescriptions like Her Arousal Rx are dosed locally and avoid the systemic side-effect profile of oral options.
How it works
Skip the waiting room. Share your sexual-wellness goals and medical history privately, get evaluated by Dr. Ressalam, and — if appropriate — your prescription ships discreetly.
Application protocol
Apply 15–30 minutes before intimacy, or as your provider directs. The cream begins working within 10–20 minutes and effects last approximately 60–90 minutes.
Both you and any partner should wash hands before application. Topical Alprostadil can transfer if not contained.
Apply a pea-sized amount to the clitoral and vulvar area. A thin layer is sufficient — more does not increase effect.
Gently massage into the tissue for 30–60 seconds. Allow 10–20 minutes for absorption before activity.
Do not allow the cream to come into contact with sensitive eye, mouth, or open-skin tissue. Use a barrier method if appropriate.
Do not exceed your provider's prescribed frequency (typically up to once daily). Wash applicator finger or wear a finger cot.
Apply 15–30 minutes before anticipated intimacy. Effects build within 10–20 minutes and last 60–90 minutes.
A brief warm or tingling sensation after application is expected — that's the vasodilation working. Sharp burning is not normal; stop and contact your provider.
Her Arousal Rx works each time you apply it. It does not change your baseline physiology — apply when you want the effect.
Avoid Vitamin C serums or chemical exfoliants on the same nights. Discuss layering with your provider.
What to expect
10–20 min
Onset
Vasodilation begins. Most patients feel a subtle warmth and increased sensitivity at the application area.
30–45 min
Peak
Maximum vascular and neural response. Optimal window for intimacy.
60–90 min
Sustained
Effects gradually decline. Some patients report continued sensitivity past the peak window.
2–4 hours
Return to baseline
Vasoactive effects subside. No residual systemic effect. Reapply as directed for next session.
Long term
No tolerance
Her Arousal Rx works each time without building tolerance. Many patients use it ongoing for years.
Timing reflects average response from clinical literature on topical vasoactive compounds. Individual results vary based on baseline cardiovascular health, age, and underlying causes of arousal concerns.
Your questions
Most patients feel onset within 10–20 minutes of application, with peak effect at 30–45 minutes and sustained activity for 60–90 minutes. Apply 15–30 minutes before intended intimacy.
Topical Alprostadil can transfer through skin contact. If your partner has cardiovascular conditions or takes nitrates, use a barrier method or wash the application area before contact.
Not in all cases. Nitrates, certain blood-pressure medications, and recent cardiac events are contraindications. Tell Dr. Ressalam your full medication list during intake — she will review carefully before prescribing.
Yes — Her Arousal Rx is non-hormonal and works locally on tissue. It does not interact with systemic hormones and can be used alongside contraceptives or HRT.
No. The actives in Her Arousal Rx work pharmacologically each time you apply them. There's no tolerance buildup the way there can be with some oral medications.
Addyi is a daily oral pill that affects neurotransmitters and works on desire. Her Arousal Rx is a topical applied before intimacy that works on local blood flow, smooth muscle, and sensitivity. Different mechanism, different use case.
More for skin and hair
Report negative side effects of prescription drugs to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.