Estriol 0.3%
Bioidentical estrogen
A weak estrogen used topically. Binds to estrogen receptors in skin cells, signaling collagen and ceramide production that drops dramatically after menopause.
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RxPrescription Included
TriActive Face Rx Cream
A menopausal skincare prescription that pairs bioidentical Estriol with two supporting actives — restoring fullness, hydration, and barrier integrity.
$95/ 30-day supply
Three actives at the root of hormonal skin aging: topical estrogen (Estriol) restores collagen signaling, Hyaluronic Acid replaces lost moisture, Niacinamide rebuilds the barrier.
Important Safety Information⚕️
Consultation Included
This is a prescription-strength product. Your order includes a free medical consultation with one of our licensed providers.
How it works:
- • Complete your online health intake after checkout.
- • A provider will review your information within 24-48 hours.
- • If approved, your prescription is sent to our pharmacy for discreet shipping.
If our providers determine this treatment isn't appropriate for you, your card authorization is released — you're never charged.
🔒 HIPAA Secure
🧪 Compounded in USA
📋 No Charge until approved
Plumper Skin✦Restored Elasticity✦Hydrated Glow✦Strengthened Barrier✦Plumper Skin✦Restored Elasticity✦Hydrated Glow✦Strengthened Barrier✦Plumper Skin✦Restored Elasticity✦Hydrated Glow✦Strengthened Barrier✦
Plumper Skin✦Restored Elasticity✦Hydrated Glow✦Strengthened Barrier✦Plumper Skin✦Restored Elasticity✦Hydrated Glow✦Strengthened Barrier✦Plumper Skin✦Restored Elasticity✦Hydrated Glow✦Strengthened Barrier✦
Proven Ingredients
Why our formula works
Three actives, each addressing one of menopause's major effects on skin. Compounded fresh, dosed for your skin, supervised by a board-certified physician.
Hyaluronic Acid 0.5%
Deep hydration
Holds up to 1000× its weight in water. Pulls moisture into the dermis from underlying tissue and atmospheric humidity, plumping fine lines.
Niacinamide 4%
Barrier repair
Increases ceramide production, calms inflammation, and visibly evens tone. Essential support for menopausal skin's weakened barrier.
“
By their fifties, my patients tell me their skin feels like a stranger's. The right Rx changes that within months.
Dr. Annie Ressalam, MD
Internist · Medical Director, HerTeleMeds
The science
How menopause changes skin
Estrogen drives much more than reproductive cycles — it's also a key signal for collagen, oil, and barrier health. Once it falls, three things happen quickly. That's why a real menopause anti-aging strategy starts at the hormone, not the moisturizer.
30%
Collagen lost in 5 yrs
Collagen production drops by roughly 30% in the first five years post-menopause, accelerating fine lines and loss of fullness.
↓ 50%
Sebum production
Sebum and ceramide synthesis fall sharply. Skin feels drier despite the same moisturizer routine that worked before.
↑ pH
Barrier weakens
Skin pH rises from ~5.5 toward 6.0+, weakening the acid mantle. Reactivity, redness, and irritation become more common.
Trusted by thousands
Real women seeing real results
Three months in, my reflection looks like me again — not a tired, drier version of me.
— HTM Patient, CA
My skin felt like a stranger's after menopause. TriActive brought it back home.
— HTM Patient, TX
Plumper, softer, less reactive. The first thing in fifteen years that actually moved the needle.
— HTM Patient, FL
Personalize your treatment
Top 3 concerns by age
Hair thinning has different drivers at different life stages. Here's how HairMax addresses the most common concerns at each.
Perimenopausal dryness
Hormonal swings reduce sebum production. Hyaluronic Acid + Niacinamide restore moisture without heavy occlusion.
Loss of glow
Cell turnover slows. Niacinamide brightens tone while Estriol re-engages the collagen signal that gives skin its bounce.
Early fine lines
Crow's feet and forehead lines deepen as collagen drops. Topical Estriol slows the loss at its hormonal source.
The mechanism
Three mechanisms, one cream
Each active addresses a different consequence of estrogen decline. Together, they restore what menopause takes.
I
Restore estrogen signaling
Estriol binds to estrogen receptors in skin cells, reactivating collagen and ceramide production that menopause shut down.
II
Lock in deep moisture
Hyaluronic Acid pulls water into the dermis from underlying tissue and atmospheric humidity, plumping fine lines from below.
III
Strengthen the barrier
Niacinamide rebuilds ceramides, calms inflammation, and lowers skin reactivity that rises with estrogen loss.
Eligibility
Is TriActive right for you?
Estriol is a topical hormone. Most women experiencing menopausal skin changes are excellent candidates — but a few situations require a conversation with your provider before starting.
Good fit if you are
- • For external facial use only. Valid prescription required.
- • Contraindicated for patients with a personal history of hormone-sensitive cancer (breast, endometrial, ovarian).
- • Not for use during pregnancy, breastfeeding, or while trying to conceive.
- • Tell your provider about all current medications and any history of blood clots, stroke, or liver disease.
- • Daily broad-spectrum SPF 30+ is required throughout treatment.
- • Avoid breast tissue and mucous membranes when applying. Wash hands thoroughly after each application.
- • Discontinue and contact your provider if breast tenderness, abnormal bleeding, persistent rash, or other systemic symptoms occur.
Talk to your provider before starting if
- !You have a personal history of breast cancer or other hormone-sensitive cancer.
- !You are pregnant, breastfeeding, or trying to conceive.
- !You are currently on systemic HRT or estrogen replacement therapy.
- !You have a history of blood clots, stroke, or liver disease.
Dr. Ressalam reviews these factors during the intake — TriActive is only prescribed when it's appropriate. If declined, your card authorization is released and you are never charged.
Pricing
Compare to traditional treatment
TriActive bundles compounded Estriol + Hyaluronic Acid + Niacinamide, a physician visit, and discreet shipping into one monthly cost.
TriActive Rx
Traditional regimen
Monthly cost
$95 / mo
$220–$450+
Dermatologist visit
Included
$150–$300 separate
Number of products
1 cream
2–3 separate Rx + topical HRT
Shipping
Free, discreet
Pharmacy pickup
Provider follow-up
Anytime
Per appointment
Traditional regimen estimate based on dermatologist or gynecologist consultation, compounded topical Estriol cream prescribed separately, plus adjunct hydrating and barrier-repair skincare in 2026.
How it works
Get started without a visit
Skip the waiting room. Tell us about your skin and menopause history, get evaluated by Dr. Ressalam, and — if appropriate — your prescription ships free.
- 1Answer a few questions about your health
- 2Dr. Ressalam reviews your submission
- 3Get approved (usually within 24 hours)
- 4Your prescription ships straight to you
- 5Stay supported with clinician guidance anytime
Application protocol
How to apply TriActive Rx
TriActive is a PM treatment. Apply consistently — collagen rebuilding takes 12+ weeks. Your provider may adjust the protocol for sensitive skin.
- 01
Cleanse thoroughly
Wash with a gentle, non-foaming cleanser. Pat skin completely dry — moisture dilutes the active and reduces efficacy.
- 02
Apply at night, face only
Pea-sized amount across cheeks, jawline, and neck. Avoid eyes, lips, and breast tissue (Estriol is not for body use).
- 03
Moisturize over top
After 10–15 minutes, layer a fragrance-free moisturizer. The Hyaluronic Acid in TriActive works best with an occlusive layer on top.
- 04
SPF 30+ every morning
Mandatory. Sun exposure accelerates the very collagen loss TriActive treats. Broad-spectrum SPF is non-negotiable.
When to apply
Apply at night, before moisturizer. Estriol works during the skin's overnight repair cycle when collagen signaling peaks.
Initial irritation
Mild tingling in week 1 is normal as your barrier adapts. Sustained redness or rash means stop and contact your provider.
Patience matters
Collagen rebuilding is slow. Most patients see meaningful change at week 12, with full results at week 24+.
Layering with actives
Avoid Vitamin C serums or chemical exfoliants on the same nights. Discuss layering with your provider.
What to expect
Your results timeline
Wk 1–4
Hydration in
Skin feels softer and looks dewier. Hyaluronic Acid plumps the surface within days; Estriol begins working at the receptor level.
Wk 5–8
Texture smooths
Crepey texture starts to even out. Niacinamide visibly strengthens the barrier; redness and reactivity calm.
Wk 9–12
Firming begins
Collagen rebuilding becomes visible. Fine lines around eyes and mouth soften. Most patients see a clear before/after by week 12.
Wk 16–20
Lasting fullness
Cheek and jawline volume noticeably restored. The cumulative effect of three actives compounds.
Wk 24+
Maintenance
Continued nightly use preserves gains. Provider may adjust frequency at follow-up to a maintenance schedule.
Timing reflects average response from clinical literature on topical Estriol and supporting actives. Individual results vary based on baseline skin condition, hormonal status, and consistency of use.
Your questions
Frequently asked
Is topical Estriol safe?
+
Estriol is the weakest of the three estrogens (estriol, estrone, estradiol) and is widely used topically in Europe and increasingly in the US for menopausal skin and vulvar care. At 0.3% applied to facial skin, systemic absorption is low. Your provider screens for contraindications before prescribing.
Can I use this if I have a history of breast cancer?
+
Topical Estriol may not be appropriate if you have a personal history of hormone-sensitive cancer. Tell Dr. Ressalam during the intake — she will not prescribe TriActive in that case, and your card authorization is released without charge.
Will Estriol affect my hormone levels systemically?
+
Topical 0.3% Estriol used facially has minimal systemic absorption — measurable but well below levels associated with systemic hormone therapy. If you are on systemic HRT, mention it during the intake so your provider can coordinate.
Can I use TriActive with my regular HRT?
+
Possibly, but only with provider coordination. Combining systemic HRT with topical Estriol could push your total estrogen exposure higher than intended. Dr. Ressalam will weigh your full picture before approving.
How quickly will I see results?
+
Hydration improvements within 1–2 weeks. Texture and barrier improvements by week 4–8. Visible firming and fine-line reduction at week 12. Full collagen rebuilding takes 24+ weeks.
What happens if I stop using it?
+
Hydration improvements fade within weeks. Collagen gains decline gradually as estrogen signaling returns to your baseline. Most patients use TriActive long-term as a maintenance therapy.
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Important Safety Information
- • For external facial use only. Valid prescription required.
- • Contraindicated during pregnancy, breastfeeding, or trying to conceive — Estriol is a topical hormone.
- • Daily broad-spectrum SPF 30+ is required throughout treatment.
- • Avoid contact with eyes, lips, and mucous membranes. Wash hands thoroughly after application.
- • Discontinue and contact your provider if excessive redness, blistering, or rash occurs.
- • Do not exceed 6 months of continuous use without provider reassessment.
Report negative side effects of prescription drugs to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.