Tretinoin 0.05%
Cell renewal
The gold-standard prescription retinoid. Speeds cell turnover from a 28-day to a 21-day cycle, smoothing texture and softening fine lines.
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RxPrescription Included
Tone Restore Face Rx Cream
A prescription-strength retinoid cream that renews skin at the cellular level — for visibly brighter, firmer, smoother skin.
$92/ 30-day supply
Four actives that compound: Tretinoin renews cells, Tranexamic Acid fades pigmentation, Niacinamide strengthens the barrier, and Panthenol soothes throughout.
Important Safety Information⚕️
Consultation Included
This is a prescription-strength product. Your order includes a free medical consultation with one of our licensed providers.
How it works:
- • Complete your online health intake after checkout.
- • A provider will review your information within 24-48 hours.
- • If approved, your prescription is sent to our pharmacy for discreet shipping.
If our providers determine this treatment isn't appropriate for you, your card authorization is released — you're never charged.
🔒 HIPAA Secure
🧪 Compounded in USA
📋 No Charge until approved
Boosted Cell Renewal✦Brighter Tone✦Smoother Texture✦Refined Pores✦Boosted Cell Renewal✦Brighter Tone✦Smoother Texture✦Refined Pores✦Boosted Cell Renewal✦Brighter Tone✦Smoother Texture✦Refined Pores✦
Boosted Cell Renewal✦Brighter Tone✦Smoother Texture✦Refined Pores✦Boosted Cell Renewal✦Brighter Tone✦Smoother Texture✦Refined Pores✦Boosted Cell Renewal✦Brighter Tone✦Smoother Texture✦Refined Pores✦
Proven Ingredients
Why our formula works
Four prescription actives that work in different layers of the skin — together they renew cells, even tone, strengthen the barrier, and keep irritation low.
Tranexamic Acid 3%
Pigmentation
Inhibits the inflammatory pathway that drives melasma and post-acne marks. Pairs with Tretinoin to fade dark spots from two angles.
Niacinamide 4%
Barrier repair
Strengthens the skin barrier, calms redness, and reduces the irritation that comes with starting a retinoid. Critical for tolerance.
Panthenol 3%
Soothing humectant
Provitamin B5 — pulls moisture into the skin while calming any retinoid reactivity. Keeps skin comfortable through the adjustment period.
“
Skin renews itself every 28 days. Prescription Tretinoin makes those days count.
Dr. Annie Ressalam, MD
Internist · Medical Director, HerTeleMeds
The science
How retinoids work
Tretinoin is the most studied prescription retinoid in dermatology. Three things happen, week after week of nightly use.
28 → 21d
Faster cell turnover
Tretinoin shortens the skin's renewal cycle. Old, dull cells shed faster; fresh, even-toned cells reach the surface.
↑ Collagen
Built-in firming
Tretinoin stimulates fibroblasts to produce new collagen. Fine lines visibly soften over 12–24 weeks.
↓ Melanin
Lighter pigmentation
Tretinoin disperses pigment clumps and pairs with Tranexamic Acid to fade dark spots and post-acne marks.
Trusted by thousands
Real women seeing real results
My skin texture is the smoothest it's been since my twenties. Sunspots are noticeably lighter.
— HTM Patient, VA
I had peeling for the first month. By week 10 my skin looked years younger.
— HTM Patient, GA
Faded my post-acne marks I thought I was stuck with forever. The retinoid worked.
— HTM Patient, MD
Personalize your treatment
Top 3 concerns by age
Skin concerns evolve at every decade. Here's how Tone Restore Rx addresses the most common ones at each life stage.
Post-acne marks
Lingering pigmentation from breakouts. Tretinoin + Tranexamic Acid fade marks at two layers — turnover and inflammation.
First fine lines
Crow's feet and forehead lines beginning. Nightly Tretinoin slows their progression and softens what's already there.
Uneven texture
Roughness, dullness, occasional bumps. Faster cell turnover smooths the surface within 8–12 weeks.
The mechanism
Four mechanisms, one cream
Each active does one thing well. Together, they renew, even, strengthen, and soothe — in a single nightly application.
I
Renew at the cellular level
Tretinoin shortens the skin's 28-day turnover cycle, surfacing fresh, even cells faster than skin does on its own.
II
Fade pigmentation
Tranexamic Acid blocks the inflammatory melanin pathway that drives melasma and post-acne marks.
III
Strengthen the barrier
Niacinamide rebuilds ceramides and calms redness — essential for keeping retinoid irritation low.
IV
Soothe through adjustment
Panthenol pulls moisture in and calms any reactivity from Tretinoin's acceleration. Keeps skin comfortable.
Eligibility
Is Tone Restore right for you?
Tretinoin is well-tolerated by most adults — but a few situations require a conversation with your provider before starting.
Good fit if you are
- ✓Looking to address fine lines, uneven tone, post-acne marks, or rough texture with prescription-strength actives.
- ✓Comfortable with a 4–8 week adjustment period of mild dryness or peeling as skin recalibrates.
- ✓Willing to commit to daily SPF — non-negotiable on any retinoid.
Talk to your provider before starting if
- !You are pregnant, breastfeeding, or trying to conceive — Tretinoin is contraindicated.
- !You have severe rosacea, active eczema, or unusually sensitive/reactive skin.
- !You've recently had chemical peels, laser treatments, or microneedling.
- !You're currently using other prescription retinoids or strong exfoliating actives.
Dr. Ressalam reviews these factors during the intake. If Tone Restore isn't the right fit, your card authorization is released and you are never charged.
Pricing
Compare to traditional treatment
Tone Restore bundles compounded Tretinoin + Tranexamic Acid + Niacinamide + Panthenol, a doctor visit, and discreet shipping into one monthly cost.
Tone Restore Rx
Traditional regimen
Monthly cost
$92 / mo
$180–$350+
Dermatologist visit
Included
$150–$300 separate
Number of products
1 cream
2–3 separate Rx + serums
Shipping
Free, discreet
Pharmacy pickup
Provider follow-up
Anytime
Per appointment
Traditional regimen estimate based on dermatologist consultation, branded prescription Tretinoin (e.g., Retin-A), compounded Tranexamic Acid, and adjunct barrier-repair skincare in 2026.
How it works
Get started without a visit
Skip the waiting room. Tell us about your skin and any sensitivities, get evaluated by Dr. Ressalam, and — if appropriate — your prescription ships free.
- 1Answer a few questions about your health
- 2Dr. Ressalam reviews your submission
- 3Get approved (usually within 24 hours)
- 4Your prescription ships straight to you
- 5Stay supported with clinician guidance anytime
Application protocol
How to apply Tone Restore Rx
Tone Restore is a PM treatment. Start every other night for the first 2–4 weeks, then move to nightly. Your provider may adjust the protocol for sensitive skin.
- 01
Cleanse thoroughly
Wash with a gentle, non-foaming cleanser. Pat skin completely dry — moisture dilutes the active and reduces efficacy.
- 02
Apply at night, face only
Pea-sized amount across cheeks, forehead, chin. Avoid eyes, nostrils, lips, and broken skin. Wait 20 minutes after cleansing.
- 03
Moisturize over top
After 10–15 minutes, layer a fragrance-free moisturizer. This minimizes Tretinoin's drying effect during the adjustment period.
- 04
SPF 30+ every morning
Mandatory. Tretinoin increases photosensitivity; without SPF, results reverse and sun damage accelerates. Broad-spectrum is non-negotiable.
When to apply
Apply at night only. Tretinoin increases photosensitivity, so PM-only use protects the active and your skin.
Retinoid uglies
Mild peeling, dryness, or breakouts in weeks 2–6 are common as cell turnover speeds up. Push through; it resolves by week 8.
Patience matters
Texture and tone smooth by week 8. Fine-line softening visible at week 12. Maximum collagen rebuilding takes 24+ weeks.
Layering with actives
Avoid Vitamin C serums or chemical exfoliants on the same nights. Discuss layering with your provider.
What to expect
Your results timeline
Wk 1–4
Adjustment phase
Skin acclimates. Mild peeling, dryness, or temporary breakouts are normal as cell turnover speeds up. Push through with consistent moisturizer.
Wk 5–8
Texture smooths
Adjustment subsides. Roughness and dullness visibly reduce. Niacinamide barrier repair becomes evident.
Wk 9–12
Tone evens
Tranexamic Acid begins fading dark spots and post-acne marks. Most patients see clear before/after by week 12.
Wk 16–20
Firming begins
Collagen rebuilding visible. Fine lines around eyes and mouth soften. Skin reflects light differently.
Wk 24+
Compounding results
Maximum effect builds over time. Most patients use Tone Restore long-term for sustained anti-aging.
Timing reflects average response from clinical literature on topical Tretinoin. Individual results vary based on baseline skin condition, retinoid tolerance, and consistency.
Your questions
Frequently asked
Why are my skin getting worse before it gets better?
+
Tretinoin accelerates cell turnover, which can surface congestion in the first 2–6 weeks. This "retinoid adjustment" is normal and resolves by week 8 in most patients. Push through with consistent moisturizer.
Can I use this if I'm pregnant or breastfeeding?
+
No. Tretinoin is contraindicated during pregnancy and breastfeeding. Tell your provider before starting if you are pregnant, planning pregnancy, or nursing.
Why is SPF mandatory with this treatment?
+
Tretinoin increases photosensitivity. Without daily broad-spectrum SPF 30+, sun exposure can damage freshly-renewed cells and reverse your progress. Non-negotiable on any retinoid.
How does Tone Restore differ from over-the-counter retinols?
+
OTC retinols are weaker precursors that the skin must convert before they work. Tretinoin is the active form — significantly stronger and supported by 50+ years of clinical research.
Can I layer this with my Vitamin C or chemical exfoliants?
+
Avoid layering on the same evening — they can compound irritation. Most patients use Tone Restore at night and Vitamin C in the morning. Skip exfoliants on Tretinoin nights.
How long until I see results?
+
Texture smooths by week 8. Tone evens by week 12. Fine-line softening visible at week 16. Maximum collagen-driven firming takes 24+ weeks of consistent nightly use.
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Important Safety Information
- • For external facial use only. Valid prescription required.
- • Contraindicated during pregnancy, breastfeeding, or while trying to conceive — Tretinoin carries teratogenic risk.
- • Daily broad-spectrum SPF 30+ is required throughout treatment.
- • Avoid contact with eyes, lips, nostrils, and broken or irritated skin. Wash hands thoroughly after each application.
- • Initial peeling, redness, or dryness in weeks 2–6 is common ("retinoid adjustment") and typically resolves by week 8.
- • Discontinue and contact your provider if severe rash, blistering, or persistent burning occurs.
- • Avoid combining with other prescription retinoids, chemical peels, or strong exfoliants without provider guidance.
Report negative side effects of prescription drugs to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.